Pk-pd Integration and Pk-pd Modelling: Alternatives to Dose Titration Studies for Selecting Optimal Dosage Schedules of Antimicrobial Drugs
نویسنده
چکیده
4. There are universally applicable formulae for systemically acting (including antimicrobial) drugs which: (a) define the relationship between the 3 pivotal pharmacokinetic (PK) parameters, clearance, volume of distribution and elimination half-life; (b) define drug action (pharmacodynamics, PD) quantitatively through the sigmoidal Emax equation, linking concentration to effect; (c) predict a potentially optimal dose. A PK-PD approach to predicting dosage (as an alternative to dose titration studies) is possible for most drugs and many diseases.
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تاریخ انتشار 2011